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Yi Sang
Korean writer (1910–1937)
In this Korean name, the family name is Kim.
Yi Sang | |
|---|---|
| Born | Kim Haegyŏng September 23, 1910 Keijō, Keiki-dō, Korea, Empire of Japan |
| Died | April 17, 1937(1937-04-17) (aged 26) Tokyo, Empire of Japan |
| Occupation(s) | Poet, Novelist, Architect, Painter, Illustrator |
| Organization | Guinhoe |
| Notable work | Crow's Eye View The Wings |
| Movement | Modernism |
| Hangul | 이상 |
| Hanja | 李箱 |
| Revised Romanization | I Sang |
| McCune–Reischauer | I Sang |
| Hangul | 김해경 |
| Hanja | 金海卿 |
| Revised Romanization | Gim Haegyeong |
| McCune–Reischauer | Kim Haegyŏng |
Kim Haegyŏng (Korean: 김해경; Hanja: 金海卿; September 23, 1910 – April 17, 1937), also known by his art nameYi Sang (이상; 李箱) was a writer and poet who lived in Korea under Japanese rule. He is well known for his poems and novels, such as Crow's Eye View and The Wings. He is considered as a pivotal and revolutionary figure of modern Korean literature.
Biography
Early life
Kim Haegyŏng was born in Seoul, Korea, on September 23, 1910, as the eldest son of Kim Yeun-chang and Park Se-chang. Yi's great-grandfather, Kim Hak-jun, held the rank of 'Jeong 3 Pum Dangsangwan' (정3품 당상관 관직: 도정; 都正) in the Joseon Dynasty. He lived in a very affluent household, but the annexation of Korea by Japan led to a decline in the family's fortunes. His father worked in letterpress printing for a palace before his birth, but after an accident that cut off his finger, he became a barber instead. Yi Sang was raised by his uncle Kim Yeon-Pil (김연필; 金演弼) as an adoptive son since 1913, as Yeon-Pil and his wife had no children at the time of his birth. Later, however, Yeon-Pil took Kim Young-Sook (김영숙; 金英淑) as his concubine and the son she already had, Kim Moon-Kyung (김문경; 金汶卿), became a legal son of Yeon-Pil. Yi Altered profiles of gene expression reflect the reprogramming of intestinal epithelial cells during their maturation along the crypt-luminal axis. To focus on genes important in this process, and how they in turn are regulated, we identified 14 transcripts commonly downregulated in expression during lineage-specific maturation of the immortalized cell lines Caco-2 (absorptive), HT29Cl16E (goblet), and HT29Cl19A (secretory) induced by contact inhibition of growth or the short-chain fatty acid butyrate. One such gene, Mybl2 (Myb-related protein B), has been linked to the stem cell phenotype, and we report is also markedly suppressed in maturing cells along the crypt-luminal axis in vivo. Mybl2 is not significantly downregulated transcriptionally during colon cell maturation, but we identified a potential micro-RNA (miRNA)-binding sequence in the Mybl2 3′-untranslated region that mediates reporter gene suppression in differentiating colon cells. Accordingly, miRNAs predicted to bind this functional target are upregulated in differentiating colon epithelial cells in vitro and in vivo; expression of one of these, hsa-miR-365 (but not hsa-324–5p), suppresses Mybl2 protein expression in proliferating Caco-2 cells. These data demonstrate that miRNA silencing plays an important role in regulating gene expression in maturing colon epithelial cells, and that utilizing a target-centered approach, rather than profiling global miRNA expression, can identify physiologically relevant, functional miRNAs. Keywords: differentiation, intestine, micro-RNA, crypt-luminal axis normal intestinal homeostasis is dependent on reprogramming of highly proliferative, multipotent stem/progenitor cells into enterocytic, goblet, and enteroendocrine cells as they migrate along the crypt axis toward the lumen and Paneth cells that remain at the bottom of the crypt. Stem and progenitor cells at the crypt base robustly express genes that promote cell cycling, driving high levels of ce Publications: https://www.ncbi.nlm.nih.gov/myncbi/young-hwan.jo.2/bibliography/public/ Recent Publications (2012- present) A. ORGAN-BRAIN CROSSTALK 1. Jo, YH, Differential transcriptional profiles of vagal sensory neurons in female and male mice. Front. Neurosci. 18:1393196 (2024) B. HYPOTHALAMIC POMC NEURONS AND ENERGY METABOLISM 1. Choi YN, Min HY, Hwang JY, and Jo YH, Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity. Life Science Alliance (2022) PMCID: PMC9418835 2. Kwon EJ, Joung HY, Liu SM, Chua SC Jr, Schwartz GJ, and Jo YH, Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production. Nature Communications (2020); 11(1):6295. doi: 10.1038/s41467-020-20160-w 3. Kwon EJ and Jo YH, Activation of the ARCPOMC->MeA projection reduces food intake. Frontiers in Neural circuits (2020) https://doi.org/10.3389/fncir.2020.595783 4. Jeong JH, Lee DK, Liu S-M, Chua SC Jr., Schwartz GJ, and Jo YH, Activation of Temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLOS Biology (2018), 16 (4):e2004399 (Research highlight in Nature, Top 10% cited article in PLOS biology in 2018-2019, Featured article in PLOS Biology) 5. Lee D.K., Jeong J.H., Chun S.-K., Chua S.C. Jr. and Jo Y.H Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons. Nature Commun. (2015) 26;6:6618. doi: 10.1038/ncomms7618 6. Lee DK, Jeong JH, Oh SH and Jo YH Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current. PLOS One (2015) Mar 17;10(3):e0119457 C. CENTRAL CHOLINERGIC REGULATION OF ENERGY METABOLISM 1. Jae Hoon Jeong, Dong Kun Lee, and Young-Hwan Jo, Cholinergic neurons in the dorsomedial hypothalamus regulates food intake. Molecular metabolism (2017), Jan 12;6(3):306-312 2. Jeong J.H., Woo Y.J., Chua S Corresponding Research Fellow Star and Planet Formation. Supermassive Black Holes. Cosmology and Early Universe. Interferometry.Abstract
賀曾樸 Ho, Paul
研究興趣
Research Highlights