Marcy martinez biography template

Abstract

The aim of this study was to determine whether self-collected pure saliva (SCPS) is comparable to nasopharyngeal (NP) swabs in the quantitative detection of SARS-CoV-2 by RT-PCR in asymptomatic, mild patients with confirmed COVID Thirty-one patients aged from 18 to 85 years were included between 9 June and 11 December A SCPS sample and a NP sample were taken for each patient. Quantitative PCR was performed to detect SARS-CoV-2 viral load. Results of SCPS vs. NP samples testing were compared. Statistical analyses were performed. Viral load was significantly correlated (r = ). The concordance probability was estimated at %. In symptomatic adults, SCPS performance was similar to that of NP swabs (Percent Agreement = %; p = ). Thus, the salivary test based on pure oral saliva samples easily obtained by noninvasive techniques has a fair agreement with the nasopharyngeal one in asymptomatic, mild patients with a confirmed diagnosis of COVID

Keywords: saliva, viral load, COVID, nasopharyngeal, SARS-CoV-2

1. Introduction

SARS-CoV-2 is found in nasopharyngeal (NP) secretions, and its viral load is consistently high in the saliva mainly in the early stage of the disease [1]. Saliva is considered a readily available diagnostic source for SARS-CoV-2 screening; however, biologically, the diagnostic sensitivity appears to be lower [2,3]. The sampling techniques studied are mainly based on deep-throat saliva [4], oropharyngeal swabs, and saliva from sputum after stimulation. These saliva samples are considered to be “enhanced” [5].

Certain regions of the world, such as Hong Kong, have already adopted a saliva testing outpatient program in their mass-screening protocols [6]. In February , the saliva test was authorized to screen populations in France on a massive scale. The test is based on self-collected, pure oral saliva followed by PCR analysis. However, little is known about differences in the performance of self-collected pure saliva (SCPS) versus NP sam

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Mass, E, 4vv, orch, , os ()

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Graduale (Thou Glory of Jerusalem), T, orch, ps () [addition to Mass, op.5]

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O praise the Lord, all ye nations (Ps cxvii) ()

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Choral Responses (): Nunc dimittis (Bible: Luke ii), With prayer and supplication (Bible: Philippians iv.6–7), Peace I leave with you (Bible: John iv)

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Festival Jubilate (Ps c), D, 7vv, orch, , ps ()

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Bethlehem (G.C. Hugg) ()

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Alleluia, Christ is risen (after M. Weisse, C.F. Gellert, T. Scott, T. Gibbons) (), arr. with vn obbl ()

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Teach me thy way (Ps lxxxvi–12),

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Peace on earth (E.H. Sears) ()

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Help us, O God (Pss lxxix.9, 5; xlv.6; xliv), 5vv ()

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A Hymn of Freedom: America (S.F. Smith), 4vv, org/pf (), rev. with text O Lord our God arise ()

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Service in A, S, A, T, B, 4vv, org: Te Deum, Benedictus (), rev. omitting Gloria, ; Jubilate Deo; Magnificat; Nunc dimittis ()

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All hail the power of Jesus’ name (E. Perronet), 4vv, org/pf, ()

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Thou knowest, Lord (J. Borthwick), T, B, 4vv, org ()

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Canticles (): Bonum est, confiteri (Ps xcii. 1–4), S, 4vv, org; Deus misereatur (Ps lxvii); Cantate Domino (Ps xcviii); Benedic, anima mea (Ps ciii)

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Te Deum, f, T, male chorus 3vv, org, ()

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Constant Christmas (P. Brooks), S, A, 4vv, org ()

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The Lord is my shepherd (Ps xxiii), female chorus 3vv, org ()

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I will lift up mine eyes (Ps cxxi), 4vv ()

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Benedictus es, Domine, Benedictus (Bible: Luke i–81), B, 4vv, org ()

Let this mind be in you (Bible: Philippians ii.5–11), S, B, 4vv, org ()

Lord of the worlds above (I. Watts), S, T, B, 4vv, org ()

Around the Manger (R. Davis), 4vv, org/pf (), version for 1v, pf/org (); rev. female chorus 3vv, org/pf (), rev. female chorus 4vv, org/pf ()

Benedicite omnia opera Domini (Bible: Daniel iii–8) ()

Communion Responses: Kyrie, Gloria tibi, Sursum corda, San

Abstract

We report 2 cases from Spain of infectious proctitis caused by Neisseria meningitidis in HIV-positive men who have sex with men. Genetic characterization of the isolates showed that they are unusual strains not found in other more frequent meningococcal locations. This finding suggests an association between specific strains and anogenital tract colonization.

Keywords: proctitis, Neisseria meningitidis, bacteria, men who have sex with men, HIV, HIV/AIDS and other retroviruses, sexually transmitted infections, molecular characterization

Pathogens that cause proctitis include Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum, and herpes simplex virus (1). We report 2 cases from Spain of proctitis caused by Neisseria meningitidis, a pathogen less frequently detected.

The first case-patient was a year-old HIV-positive man who had proctalgia and purulent anal and urethral discharges. He reported having unprotected sex with other men.

The second case-patient was a year HIV-positive man who had a purulent discharge, pain, and anal tenesmus. He reported having unprotected anal sex with other men and having previously diagnosed sexually transmitted infections.

Both patients were given a diagnosis of probable infectious proctitis. Rectal exudates samples were collected for detection of infectious agents. The first case-patient was given ceftriaxone (1 g, single intramuscular dose) and azithromycin ( g, single oral dose). The second case-patient was given ceftriaxone ( mg, single intramuscular dose). Both patients showed clinical improvement.

Routine screening for Mycoplasma spp. and nucleic acid amplification for N. gonorrhoeae and C. trachomatis yielded negative results. We isolated gram-negative diplococci from both patients on modified Martin-Lewis agar (Becton Dickinson, Franklin Lakes, NJ, USA) and identified these diplococci as N. meningitidis serogroup B by using mass spectrometry (Biotyper System; Bruker, Bille