Paola menacho biography of rory
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin’s beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism. Here we report that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed. Activation of AMPK by metformin or an adenosine analogue suppresses expression of SREBP-1, a key lipogenic transcription factor. In metformin-treated rats, hepatic expression of SREBP-1 (and other lipogenic) mRNAs and protein is reduced; activity of the AMPK target, ACC, is also reduced. Using a novel AMPK inhibitor, we find that AMPK activation is required for metformin’s inhibitory effect on glucose production by hepatocytes. In isolated rat skeletal muscles, metformin stimulates glucose uptake coincident with AMPK activation. Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders.
Gaochao Zhou, Robert Myers, Ying Li, Yuli Chen, Xiaolan Shen, Judy Fenyk-Melody, Margaret Wu, John Ventre, Thomas Doebber, Nobuharu Fujii, Nicolas Musi, Michael F. Hirshman, Laurie J. Goodyear, David E. Moller
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Items where division is "Divisions > Division of Natural Sciences > Medway School of Pharmacy"
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| Abooali, Maryam, Lall, Gurprit S., Coughlan, Karen, Lall, Harjinder S., Gibbs, Bernhard F., Sumbayev, Vadim V. (2014) Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function. Scientific Reports, 4 (6307). pp. 1-8. ISSN 2045-2322. E-ISSN 2045-2322. (doi:10.1038/srep06307) (KAR id:43771) |
| Abooali, Maryam, Yasinska, Inna M., Schlichtner, Stephanie, Ruggiero, Sabrina, Berger, Steffen M, Cholewa, Dietmar, Milošević, Milan, Bartenstein, Andreas, Fasler-Kan, Elizaveta, Sumbayev, Vadim V. and others.(hide) (2023) Activation of immune evasion machinery is a part of the process of malignant transformation of human cells. Translational oncology, 39 . Article Number 101805. ISSN 1936-5233. (doi:10.1016/j.tranon.2023.101805) (KAR id:103490) |
| Abraham, Michael H., Hassanisadi, Mostafa, Jalali-Heravi, Mehdi, Ghafourian, Taravat, Cain, William.S., Cometto-Mun˜iz, J.Enrique (2003) Draize Rabbit Eye Test Compatibility with Eye Irritation Thresholds in Humans: A Quantitative Structure-Activity Relationship Analysis. Toxicological Sciences, 76 (2). pp. 384-391. ISSN 1096-6080. (doi:10.1093/toxsci/kfg242) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10753) |
Adibkia, Khosro, Omidi, Yadollah, Javadzadeh, Ali R., Barzegar-Jalali, Mohammad, Barar, Jaleh, Maleki, Nasrin, Mohammadi, Ghobad, Nokhodchi, Ali (2007) Inhibition of Endotoxin-Induced Uveitis by Methylprednisolone Acetate Nanosuspension in rabbits. Journal of Ocular Pharmacology and Therapeutics, 23 (5). pp. 421 3rd Plurinational Legislative Assembly of Bolivia2020–2025 meeting of Bolivian legislature For a general discussion of the Bolivian government's legislative branch, see Plurinational Legislative Assembly. The 3rd Plurinational Legislative Assembly of Bolivia (Spanish: 3° Asamblea Legislativa Plurinacional de Bolivia; ALP) is the current meeting of the legislative branch of the Bolivian government, composed of the Chamber of Senators and the Chamber of Deputies. It convened in La Paz on 3 November 2020, during the final week of Jeanine Áñez's presidency, and will end in 2025. It will meet during all five years of Luis Arce's presidency. The 2020 general elections decided control of both chambers. In both the Chamber of Deputies and Senate, the Movement for Socialism retained its majority—albeit reduced from the two-thirds supermajority from the 2nd Plurinational Legislative Assembly [fr]. This assembly marks the first time women make up the majority of the legislature as a whole at 51.9 percent of parliamentarians. In the Senate, women make up the absolute majority at 55.5 percent of senators, while in the Chamber of Deputies, they reach near gender parity at 46.9 percent of deputies. This legislature has been characterized by frequent inter-party conflicts and quarrels. The ruling Movement for Socialism failed to attain a supermajority in either chamber—as it had done in the previous assemblies—granting the opposition a higher degree of discretion over decisions requiring the support of two-thirds of legislators. However, amendments to the regulations of both chambers approved by the preceding legislature shortly before this assembly's formal installation abrogated the two-thirds requirement for numerous parliamentary procedures, leading political analysts to note the effective neutralization of the opposition's ability to operate. Subsequent disputes and accusations by the opposition of abuse of parliamentary procedure pu |