Armen saghatelyan biography sample
Abstract
Olfactory bulb (OB) interneurons are continuously renewed throughout an animal's lifespan. Despite extensive investigation of this phenomenon, little is known about bulbar circuitry functioning and olfactory performances under conditions of ablated arrival of new neurons into the adult OB. To address this issue we performed morphological, electrophysiological, and behavioral analysis in mice with suppressed bulbar neurogenesis. Infusion of the antimitotic drug AraC to the lateral ventricle via 28 d osmotic minipumps abolished the arrival of newly born neurons into the adult OB without affecting the total number of granule cells. The number, dendritic arborization, and spine density of interneurons generated in adulthood, before pump installation, were also not affected by AraC treatment. As a result of ablated neurogenesis, mitral cells—the principal output neurons in the OB—receive fewer inhibitory synapses, display reduced frequency of spontaneous IPSCs, experience smaller dendrodendritic inhibition, and exhibit decreased synchronized activity. Consequently, short-term olfactory memory was drastically reduced in AraC-treated mice. In contrast, olfactory performances of AraC-treated animals were undistinguishable from those of control mice in other odor-associated tests, such as spontaneous odor discrimination and long-term odor-associative memory tasks. Altogether, our data highlight the importance of adult neurogenesis for the proper functioning of the OB network and imply that new bulbar interneurons are involved in some, but not all, odor-associated tasks.
Introduction
In the adult brain, neuronal precursors born in the subventricular zone (SVZ) migrate toward the olfactory bulb (OB), in which they differentiate into granule and periglomerular neurons (Lledo and Saghatelyan, ), establish dendrodendritic synapses with the OB principal cells (Whitman and Greer, ), display appropriate electrophysiological features (Belluzzi et al., ; Carleton et al.
Professor Armen Saghatelyan: the history of radioecology school in Armenia
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- 1. Center for Ecological-Noosphere Studies of NAS RA, Yerevan (Armenia)
Description
Professor A.K. Saghatelyan's holistic vision of the pathways and fate of chemical elements in Earth Crust and Biosphere which he inherited from USSR geochemical science, helped him to establish and promote several scientific schools in Armenia. Inter alia, Prof. Saghatelyan inspired and contributed to the Radioecology discipline development at his founded the Center for Ecological-Noosphere Studies of NAS RA (CENS). Within the series of international research projects led by Prof. Saghatelyan, a modern laboratory was created at CENS and continuous personnel training was arranged. Initial radioecological studies were implemented with the aim to assess environmental radioactivity and its relation with the main geochemical peculiarities of Armenia's territory. In Radioecology Department was re-opened at CENS as a separate unit. Prof. Saghatelyan's conceptualization allowed establishing novel radioecological monitoring net within the frame of series of national research projects. The yielded monitoring data enabled estimating the baseline activity of naturally occurring radionuclides as well as the fallout inventory of some artificial radionuclides (e.g. Cs), which is essential for early warning and rapid response system within the frames of national radiation protection and nuclear security. From Prof. Saghatelyan supervised geochemical surveys in the biggest cities and industrial zones of Armenia, which resulted in arrangement of soil sample archive at CENS. This valuable material has been using further for radioecological studies which revealed the importance of monitoring naturally occurring radionuclides and related radon hazard as well as the factors of technologically enhanced natural radioactivity. Finally, thanks to CENS's up-to-date l Retrouvez nos conseils sur (, appel non surtaxé) 18+ | Erlaubtes Glücksspiel Gemäß der White-list | Suchtrisiken | Hilfe unter 18+ Jogue com responsabilidade .Arman Saghatelyan - Armenia / Bentonit injury history
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