Aldrin cudia 2017 federal tax

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Publication number

WO2014117118A1

WO2014117118A1PCT/US2014/013274US2014013274WWO2014117118A1WO 2014117118 A1WO2014117118 A1WO 2014117118A1US 2014013274 WUS2014013274 WUS 2014013274WWO 2014117118 A1WO2014117118 A1WO 2014117118A1

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WO

WIPO (PCT)

Prior art keywords

fungal pesticide

strain

fungal

pesticide

stage

Prior art date

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Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing

1. Petitioner City of Manila is ordered to indemnify respondents Alegar Corporation, Terocel Realty Corporation, and Filomena Vda. De Legarda in the amount of P50,000.00 as attorney's fees;
   
2. Respondents Alegar Corporation, Terocel Realty Corporation, and Filomena Vda. De Legarda are in turn ordered to return the advance deposit of P 1,500,000.00 that they withdrew incident to the expropriation case; and
3. This decision is without prejudice to the right of the City of Manila to re-file their action for expropriation after complying with what the law requires.

Published in final edited form as: J Am Chem Soc. 2020 Oct 16;142(43):18599–18618. doi: 10.1021/jacs.0c08231

Abstract

Here we interrogate the structurally dense (1.63 mcbits/Å) GABA_A receptor antagonist bilobalide, intermediates en route to its synthesis and related mechanistic questions. C isotope labeling identifies an unexpected bromine migration en route to an α-selective, catalytic asymmetric Reformatsky reaction, ruling out an asymmetric allylation pathway. Experiment and computation converge on the driving forces behind two surprising observations. First, an oxetane acetal persists in concentrated mineral acid (1.5 M DCl in THF-d₈/D₂O); its longevity is correlated to destabilizing steric clash between substituents upon ring-opening. Second, a regioselective oxidation of des-hydroxybilobalide is found to rely on lactone acidification through lone-pair delocalization, which leads to extremely rapid intermolecular enolate equilibration. We also establish equivalent effects of (−)-bilobalide and the nonconvulsive sesquiterpene (−)-jiadifenolide on action potential-independent inhibitory currents at GABAergic synapses, using (+)-bilobalide as a negative control. The high information density of bilobalide distinguishes it from other scaffolds, and may characterize natural product (NP) space more generally. Therefore, we also include a Python script to quickly (ca. 132,000 molecules/minute) calculate information content (Böttcher scores), which may prove helpful to identify important features of NP space.

Graphical Abstract

Introduction.

Herbal supplements and remedies constitute a large and controversial market. Not regulated as conventional foods or drugs by the FDA, plant extracts can nevertheless contain orally bioavailable small molecules with profound effects on human biology. Successful sales, however, do not rely on the same demonstrations of efficacy and safety as approv